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Poliovirus Type 1, Type 2 and Type 3 are each grown in separate cultures of MRC-5 cells, a line of normal human diploid cells, by the microcarrier method.9,10 The cells are grown in CMRL (Connaught Medical Research Laboratories) 1969 medium, supplemented with calf serum. For viral growth, the culture medium is replaced by Medium 199, without calf serum. After clarification and filtration, the viral suspensions are concentrated by ultrafiltration, and purified by liquid chromatography steps. The monovalent viral suspensions are inactivated with formaldehyde. Monovalent concentrates of each inactivated poliovirus are combined to produce a trivalent poliovirus concentrate.Steroids are mainly used for treating acute episodes of MS. Steroids help to reduce the body's autoimmune response. In doing so, steroids help to shorten the length of an attack, and rapidly reduce inflammation. Since their use is associated with significant long-term side effects, steroids are used only for short periods of time. Side effects of steroids include psychosis, bloating, insomnia (sleeping problems), headache, bone loss, suppression of the immune system, moon (rounded) face, stomach ulcers, and increases in blood sugar.

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For full details, see the summary of product characteristics (also part of the EPAR).Increased nonfasting triglycerides (at least 751 mg/dL) and glucose (greater than 250 mg/dL) have been reported in up to 11% and up to 5% of patients, respectively.[Ref]

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Fexofenadine, is similar to the other second generation antihistamines loratadine (Claritin), cetirizine (Zyrtec) and azelastine (Astelin). Histamine is a chemical in the body that stimulates the production of mucus and the dilation of blood vessels.

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